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An animal study (male Sprague-Dawley rats) used a topical application of a water extract of Lion's Mane mushroom at concentrations of 20, 30, and 40 mg/ml (between 2%-4% concentration). This study was conducted to evaluate the effects of Lion's Mane on the rate of wound healing enclosure and histology of the healed wound. Control groups were topically applied with 0.2 ml of sterilized distilled water or the mushroom extract on a 2-cm-diameter neck wound. The lion’s mane groups had less scar tissue area at wound enclosure, and the healed wounds had fewer white blood cells (indicating less infection or pus formation) and greater levels of collagen. They also contained a greater density of new blood vessels. The report concludes, wounds dressed with Lion's Mane extract significantly enhanced the acceleration of wound healing enclosure.
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MA Abdulla et al., “Potential activity of aqueous extract of culinary-medicinal Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats,” International Journal of Medicinal Mushrooms, vol. 13, no. 1 (2011): 33–39.