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Parkinson's disease (PD) is the second most common neurodegenerative disorder that is characterized by the progressive loss of dopaminergic cells in the substantia nigra pars compacta region of the brain. Symptoms include muscle rigidity, tremors, and changes in speech and gait. After diagnosis, treatments can help relieve symptoms, but there is no known cure. Although no cure has been found yet, Lion's Mane is one of many examples of natural remedies used to reduce the symptoms associated with Parkinson's disease.
In an animal model of Parkinson’s disease, oral administration of low-dose Lion's Mane mycelium was administered for 25 days. The study showed significant improvement in oxidative stress and dopaminergic lesions in the striatum and substantia nigra, a part of the midbrain dopaminergic nucleus which has a critical role in modulating motor movement. (1) The extract was enriched with erinacine A which is mainly found in the mycelium of the mushroom, and activated through an ethanol extraction process.
Erinacine A, which is the main representative of the erinacine group, not only has an enhancing effect on Nerve Growth Factor synthesis in vitro, but also can increase NGF and catecholamine content in the locus coeruleus and hippocampus of rats after administration. This enhanced amount of NGF appears to markedly increase neuronal survival in different brain areas and substantially improve behavioral outcomes in various animal models, including the midbrain associated with Parkinson's disease. (2)
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