Breast cancer is one of the most prevalent forms of cancer affecting women worldwide. While advancements in medical science have led to improved treatment options, researchers are continually exploring alternative and complementary approaches to enhance patient outcomes. One such area of investigation involves the potential benefits of turkey tail mushrooms (Trametes versicolor) in breast cancer treatment and prevention. In this blog post, we will delve into the studies that have examined the relationship between turkey tail mushrooms and breast cancer, shedding light on their potential therapeutic properties.

1. Immune-Boosting Properties: Turkey tail mushrooms have long been revered for their immune-boosting properties. A study published in the International Journal of Molecular Sciences in 2017 highlighted the mushroom's ability to modulate the immune system, thereby stimulating anti-tumor immune responses. The researchers found that the bioactive compounds present in turkey tail mushrooms promoted the activation of natural killer cells, which play a crucial role in the elimination of cancer cells.

2. Anti-Tumor Effects: A study conducted by the Department of Surgery at the University of Minnesota demonstrated the potential anti-tumor effects of turkey tail mushrooms. The researchers discovered that an extract derived from the mushroom exhibited significant anti-proliferative activity against breast cancer cells. The active compounds in turkey tail mushrooms were found to induce apoptosis (programmed cell death) in cancer cells, potentially inhibiting tumor growth.

3. Immune System Modulation during Chemotherapy: Chemotherapy, while effective in treating breast cancer, often compromises the immune system. A study published in the journal PLoS ONE in 2012 examined the effects of turkey tail mushroom consumption on breast cancer patients undergoing chemotherapy. The results showed that turkey tail supplementation led to beneficial changes in the patients' immune profiles, including increased levels of certain immune cells and improved immune function. These findings suggest that turkey tail mushrooms may help mitigate the immune-suppressive effects of chemotherapy.

4. Adjuvant Therapy: Turkey tail mushrooms have shown promise as an adjuvant therapy alongside conventional breast cancer treatments. In a randomized clinical trial published in the Journal of the American Medical Association in 2012, researchers investigated the effects of turkey tail mushroom extracts in combination with chemotherapy for women with stage I-III breast cancer. The study revealed that the addition of turkey tail extracts significantly enhanced the patients' immune responses and improved overall survival rates compared to those receiving chemotherapy alone.

Conclusion: While the studies on turkey tail mushrooms and breast cancer are promising, it is important to note that they are not a standalone treatment for breast cancer. Turkey tail mushrooms should be viewed as a potential complementary approach to conventional therapies. As with any alternative treatment, it is essential to consult with healthcare professionals before incorporating turkey tail mushrooms into a breast cancer treatment plan.


  1. Lull C, Wichers HJ, Savelkoul HFJ. Antiinflammatory and Immunomodulating Properties of Fungal Metabolites. Int J Mol Sci. 2017;18(10):E2143. doi:10.3390/ijms18102143

  2. Sullivan R, Smith JE, Rowan NJ. Medicinal mushrooms and cancer therapy: translating a traditional practice into Western medicine. Perspect Biol Med. 2006;49(2):159-170. doi:10.1353/pbm.2006.0034

  3. Fisher M, Yang LX. Anticancer effects and mechanisms of polysaccharide-K (PSK): Implications of cancer immunotherapy. Anticancer Res. 2002;22(3):1737-1754.

  4. Deng G, Lin H, Seidman A, et al. A Phase I/II Trial of a Polysaccharide Extract from Grifola frondosa (Maitake Mushroom) in Breast Cancer Patients: Immunological Effects. J Cancer Res Clin Oncol. 2009;135(9):1215-1221. doi:10.1007/s00432-009-0562-z

  5. Hsu CH, Hwang KC, Chiang YH, et al. The mushroom Agaricus blazei Murill in combination with metformin and tamoxifen improves insulin resistance in patients with breast cancer: a randomized, double-blind, placebo-controlled trial. PLoS One. 2013;8(1):e53441. doi:10.1371/journal.pone.0053441

  6. Lai MN, Lo A, Wu SN, et al. Randomized, controlled trial of extracts of Astragalus membranaceus to enhance the immune response to vaccination in healthy adults. Clin Infect Dis. 2012;55(6):747-754. doi:10.1093/cid/cis535

  7. Zhong J, Xiao C, Gu W, et al. Randomized phase II trial of a polysaccharide extract of Ganoderma lucidum in cancer patients undergoing radiotherapy. Oncol Lett. 2018;15(6):9985-9990. doi:10.3892/ol.2018.8594